Hydroxyapatite (HA) is an inorganic insoluble mineral with the formula Ca10(PO4)6(OH)2, it has a calcium to phosphorous ratio of 1.67. Hydroxyapatite is the main mineral component of human bone; it is a bioactive ceramic utilised in hard-tissue regeneration and is an excellent choice for any tissue engineering application where a safe, biocompatible and non-resorbable material is required.
There is no difference between hydroxyapatite and hydroxylapatite. Both terms refer to Ca10(PO4)6(OH)2. Academics may prefer Hydroxy(l)apatite however Hydroxyapatite is also widely used.
Synthetic hydroxyapatite was developed to avoid any risks associated with acellular allograft or xenograft ‘natural’ bone sources and to present a scalable option to meet the growing regenerative medicine industry. Plasma Biotal’s synthetic Captal hydroxyapatite is intrinsically safe, manufactured and characterised to the latest ISO13779-6 standard(s) and optimised for each application. High flowability powders for plasma sprayed coatings are our speciality however we can provide a bespoke solution for small or large order quantities to tailor morphology, density and particle size to meet your product or research demands.
Beta-Tricalcium Phosphate, is an inorganic soluble mineral with the formula Ca3(PO4)2, it has a calcium to phosphorous ratio of 1.5. Plasma Biotal’s Captal β-TCP is a resorbable osteoinductive bioactive ceramic utilised in hard-tissue regeneration where a resorbable material is required to promote bone healing. In vivo the β-TCP is broken down by the body and Hydroxyapatite is deposited in its place. Beta-Tricalcium Phosphate is an excellent choice for any tissue engineering application where a safe, biocompatible and resorbable material is required.
Coating a metallic medical device substrate with synthetic calcium hydroxyapatite creates a composite device with the excellent load bearing mechanical properties of the device and a bioactive surface layer of coated hydroxyapatite. The high strength hydroxyapatite coating is known to enhance early bone formation and provide a physiological bone – implant bond without the drawbacks associated with bone cements. Plasma Biotal’s Captal coating service has remained state of the art for over 30 years, achieving impressive crystallinity compared to the rest of industry which contributes to long term coating stability in vivo. Our specialism in hard to coat devices, bespoke devices and or low order quantities has been developed through time in the industry since being one of the first to offer a coating service in 1991.
Dense injectable hydroxyapatite microspheres are optimised for flowability. Plasma Biotal’s tailored hydroxyapatite Captal HT microspheres are used in applications requiring initial volume filling and for supporting neocollagenesis. All of our hydroxyapatite for dermal fillers undergoes the same characterisation to meet the stringent quality control standards required to provide material for medical devices.
