Beta-tricalcium phosphate (β-TCP)

Beta-tricalcium phosphate (β-TCP) is the second most abundant form of calcium phosphate in the body, after hydroxyapatite. Beta-tricalcium phosphate (β-TCP) is a bioresorbable ceramic widely used in medical applications due to its biocompatibility and osteoconductive properties. As a calcium phosphate compound, β-TCP closely mimics the mineral component of human bone, making it a suitable scaffold material for bone regeneration and repair.

Once implanted, β-TCP gradually dissolves through osteoclast mediated resorption and is replaced by natural bone. The resorption rate of which can be influenced through factors such as density, and implant architecture, promoting healing of defects that would otherwise be too large for natural bone repair.

β-TCP is commonly used in orthopaedic surgeries, dental implants, and maxillofacial reconstruction, where it aids in filling bone defects and promoting bone growth. Its controlled resorption rate and compatibility with other biomaterials make ß-TCP a valuable option in both standalone and composite bone grafts, promoting better integration with natural bone.

At Plasma Biotal we specialise in producing tailored high-purity (≥ 95% phase pure)  β-TCP formulations, optimising our material’s chemical and physical properties to meet your specific product and research needs.

Suitable for use in:

• Dental
• Research
• Bone Graft Substitutes

Popular β-TCP Products

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  Beta-Tricalcium Phosphate (β-TCP)

  - High-purity, crystalline beta tricalcium phosphate (ß-TCP) designed for use in regenerative bone and dental therapies.
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  CAPTAL ‘ACP 1.50’ Amorphous Tricalcium Phosphate (ACP)

  - Amorphous beta-tricalcium phosphate precursor material designed for multipurpose use.

β-TCP FAQs

• What is the difference between hydroxyapatite and β-TCP?

  Both materials are calcium phosphates, and so are both similar in composition to the mineral phase of bone. Hydroxyapatite is considered only slightly soluble in vivo , whereas β-TCP is fully soluble through a cell-mediated interaction, allowing for use in fully regenerative therapies as opposed to HA which provides a permanent coating or device.

• How long does β-TCP remain in vivo before complete resorption?

  The resorption rate of β-TCP depends on factors such as the implant location, the device design, material porosity, and surface area. As β-TCP gradually resorbs, it serves as a high-purity source of calcium and phosphorus ions, supporting bone remodelling for over a year post-implantation. This makes it an excellent choice for promoting regeneration.

• How pure is Plasma Biotal’s β-TCP?

  Plasma Biotal manufactures ≥ 95% phase pure β-TCP independently verified via X-Ray Diffraction (XRD) to ASTM F1088. We have validated and documented our trace elemental impurities and can provide the data to support your compliance.